Table of Contents
Table of Contents 3
List of Tables 6
List of Figures 7
Ipsen SA, Pharmaceuticals & Healthcare, Deals By Year, 2012 to YTD 2018 8
Ipsen SA, Pharmaceuticals & Healthcare Deals By Type, 2012 to YTD 2018 9
Ipsen SA, Pharmaceuticals & Healthcare, Deals By Region, 2012 to YTD 2018 10
Ipsen SA, Pharmaceuticals & Healthcare, Deals By Therapy Area, 2012 to YTD 2018 11
Ipsen SA, Medical Devices Deals, 2012 to YTD 2018 13
Ipsen SA, Pharmaceuticals & Healthcare, Deals Summary, 2012 to YTD 2018 14
Ipsen SA, Pharmaceuticals & Healthcare, Deal Details 18
Asset Purchase 18
Ipsen Acquires Healthcare Portfolio from Sanofi for USD88.3 Million 18
Ipsen Acquires Oncology Assets from Merrimack Pharma 20
Venture Financing 22
Rhythm Pharma Raises USD41 Million in Mezzanine Financing 22
Rhythm Metabolic Raises USD40 Million in Series A Financing Round 24
Rhythm Pharma Raises US$33 Million In Series B Financing 26
Motus Therapeutics Secures Additional USD8 Million in Series B Round of Venture Funding 28
Rhythm Pharma Raises US$9.5 Million In Venture Financing 30
Partnerships 31
Arix Bioscience and Ipsen Enter into Co-Development Agreement 31
Ipsen Enters into Co-Promotion Agreement with Saol Therapeutics 32
Ipsen Enters into Research Agreement with Institute of Molecular and Cell Biology 33
Ipsen Partners with Oncodesign 34
Ipsen Enters into Research Agreement with PeptiMimesis 35
Ipsen Enters into Research Agreement with Aepodia 36
Galderma Enters into Distribution Agreement with Ipsen for Dysport in Asia-Pacific 37
Ipsen Enters into Research Agreement with Interprotein 38
Ipsen and EpiVax Enter into Partnership 39
Ipsen Enters into Research Agreement with Hannover Medical School 40
Ipsen and CNRS Enter into Agreement with CEA and University of Rennes 41
Ipsen Extends Research Agreement with Salk Institute for Biological Studies 42
Ipsen Extends Distribution Agreement with Galderma for Dysport 43
GW Pharma Enters Into Distribution Agreement With Ipsen For Sativex 45
Ipsen And Mayoly Spindler Enter Into Cross-Promotion Agreement For Primary Care Activities In France 46
Ipsen Enters Into Research Agreement With Harvard Medical School To Discover Botulinum Toxins 47
PeptiDream Expands Co-Development Agreement With Ipsen For Peptide Drugs 48
PeptiDream Enters Into Research Agreement With Ipsen To Discover Therapeutic Peptides 49
Oncodesign And Laboratory For Neurobiology and Gene Therapy Enter Into Research Agreement With Ipsen For Parkinson’s Disease 50
Ipsen Extends Distribution Agreement With Galderma For Dysport 52
Oncodesign Enters into Research Agreement with Ipsen 53
Licensing Agreements 54
Ipsen Enters into Licensing Agreement with MD Anderson 54
Merrimack Pharma Enters into Licensing Agreement with Ipsen 55
Ipsen Amends Licensing Agreement with Exelixis 56
Ipsen Enters into Licensing Agreement with 3B Pharma 57
Ipsen Enters into Licensing Agreement with Telesta Therapeutics 58
Lexicon Pharma Expands Licensing Agreement with Ipsen 59
Otonomy Enters into Licensing Agreement with Ipsen 60
Lexicon Pharma Expands Licensing Agreement with Ipsen for Telotristat Etiprate 61
Ipsen Enters into Licensing Agreement with Probi 63
Daewoong Enters Into Licensing Agreement With Ipsen Tianjin For Smecta Technology 64
Ipsen Enters Into Licensing Agreement With Inspiration Biopharma For IB1001 and OBI-1 65
Equity Offering 66
Arix Bioscience to Raise USD76.7 Million in Private Placement of Shares 66
Debt Offering 68
Ipsen Raises USD341 Million in Public Offering of 1.875% Notes Due 2023 68
Asset Transactions 69
Baxter International Completes Acquisition Of Rights To OBI- 1 And Related Assets From Ipsen And Inspiration Biopharma For USD700 Million 69
Cangene Completes Acquisition Of Rights To Hemophilia Products From Ipsen And Inspiration For US$300 Million 71
Acquisition 73
Ipsen to Acquire Equity Stake in Akkadeas Pharma 73
Ipsen Acquires Canbex Therapeutics 74
Ipsen Acquires OctreoPharm Sciences for USD57 Million 75
Ipsen Acquires Syntaxin, Life Sciences Company, For USD206 Million 76
Ipsen Sells 19.31% Stake In Spirogen, Developer Of DNA Sequence-Targeted Agents 78
Ipsen SA – Key Competitors 79
Ipsen SA – Key Employees 80
Ipsen SA – Locations And Subsidiaries 82
Head Office 82
Other Locations & Subsidiaries 82
Affiliate 84
Joint Venture 84
Recent Developments 85
Financial Announcements 85
Oct 25, 2018: Ipsen delivers strong sales growth of 20.2%1 for the third quarter of 2018 and confirms full year guidance 85
Jul 26, 2018: Ipsen delivers strong results for the first half of 2018 with sales growth of 21.5% and upgrades its guidance for full year 2018 87
Feb 15, 2018: Ipsen Delivers Strong 2017 Results with 21.1%1 Sales Growth and Core Operating Margin Increase of 3.4 Points and Expects Significant Further Growth in Sales and Margin in 2018 88
Jul 27, 2017: Ipsen Delivers Strong Sales Growth of 18.8% in the First Half of 2017 and Upgrades Its Guidance for Full Year 2017 90
Apr 27, 2017: Ipsen Reports Strong First Quarter 2017 Sales Growth of 19,1%1 98
Feb 23, 2017: Ipsen delivers strong 2016 results and expects further sales growth and margin enhancement for 2017 101
Corporate Communications 109
Sep 27, 2018: Ipsen names Dr. Yan Moore as Senior Vice President, Head of Oncology therapeutic area; and Dr. Alexander McEwan, FRCPC, as Vice President, Head of Radiopharmaceuticals 109
Mar 13, 2018: Ipsen Announces Executive Leadership Appointments 110
Jan 26, 2018: Dr Sotirios G. Stergiopoulos appointed as Ipsen Chief Medical Officer 111
Jan 12, 2018: Ipsen Appoints Richard Paulson Executive Vice-President and Chief Executive Officer of Ipsen North America 112
Apr 14, 2017: Ipsen appoints Dr. Alexandre Lebeaut as Executive Vice-President, R&D, and Chief Scientific Officer 113
Feb 06, 2017: Ipsen announces appointment of Dr. Sotirios G. Stergiopoulos as Head of Global Medical Affairs 114
Jan 20, 2017: Ipsen appoints Harout Semerjian as President, Head of Specialty Care International Region & Global Franchises 115
Product News 116
09/18/2017: U.S. FDA Approves New Indication for Ipsen’s Somatuline Depot (lanreotide) Injection for the Treatment of Carcinoid Syndrome 116
09/04/2017: Ipsen To Present Data on Somatuline at European Society of Medical Oncology congress 117
07/21/2017: Radius Health Announces that the CHMP Has Issued a Second Day-180 List of Outstanding Issues in its Regulatory Review of Eladynos (Abaloparatide-SC), a Bone Building Agent for the Treatment of Postmenopausal Women with Osteoporosis at High Risk for Fracture 118
07/03/2017: Somatuline Autogel 120 mg receives Japanese approval for a new indication for the treatment of gastro-entero-pancreatic neuroendocrine tumors 119
06/01/2017: Ipsen To Present New Data of Lanreotide at ASCO 120
06/01/2017: Ipsen To Present New Data on Investigational Compound Lu-OPS201 at ASCO 121
05/01/2018: Novel Theranostic Approach for Treating Pancreatic Cancer Patients Shows Promise 122
04/17/2017: Merrimack Appoints Daryl Drummond, Ph.D. as Head of Research 123
03/09/2017: Ipsen announces data presentation on lanreotide (Somatuline Autogel) at the European Neuroendocrine Tumor Society (ENETS) 2017 conference 124
03/09/2017: Ipsen announces presentation on the investigational compound 177Lu-OPS201 at the European Neuroendocrine Tumor Society (ENETS) 2017 conference 126
02/13/2018: Health Canada approves Ipsen Somatuline Autogel for the treatment of carcinoid syndrome in adult patients with neuroendocrine tumours (NETs) 127
01/15/2018: Ipsen To Present Abstracts On lanreotide ASCO Gastrointestinal Symposium 2018 128
Product Approvals 129
Apr 28, 2017: FDA Approves Radius Healths TYMLOS (abaloparatide), a Bone Building Agent for the Treatment of Postmenopausal Women with Osteoporosis at High Risk for Fracture 129
Mar 28, 2017: NICE says pancreatic cancer drug is not cost effective for routine NHS use 131
Mar 13, 2017: Shire’s Onivyde Rejects For Use Within NHS Scotland 132
Mar 10, 2017: Radius Health Receives Notification of PDUFA Extension for Abaloparatide-SC 133
Clinical Trials 134
Jun 01, 2017: Ipsen Announces Presentation of New Data on Irinotecan at ASCO 134
May 24, 2017: Radius Announces Positive Top-Line Results from Completed ACTIVExtend Study for TYMLOS in Postmenopausal Women with Osteoporosis 135
Apr 03, 2017: New Analysis from ACTIVE Showed Consistent Fracture Reductions for Abaloparatide-SC Across Geographies 136
Mar 27, 2017: Merrimack to Present Data on MM-398 at the 2017 American Association for Cancer Research Annual Meeting 138
Feb 01, 2017: Mayo Clinic Proceedings Publishes Positive Results from the ACTIVExtend Clinical Trial of Abaloparatide-SC in Postmenopausal Women With Osteoporosis 139
Other Significant Developments 141
Oct 04, 2018: Ipsen Joins Biotechnology Innovation Organization (BIO) to advance growth and innovation 141
Jul 10, 2018: Ipsen welcomes Frederique Vidal, Minister of Higher Education, Research and Innovation, at its new development center in Dreux 142
Jun 07, 2018: Global Biopharmaceutical Company, Ipsen Announces New Headquarters for North America will be located in Cambridge, Massachusetts 143
Appendix 144
Methodology 144
About GlobalData 144
Contact Us 144
Disclaimer 144
Ipsen SA, Pharmaceuticals & Healthcare, Key Facts, 2017 2
Ipsen SA, Pharmaceuticals & Healthcare, Deals By Year, 2012 to YTD 2018 8
Ipsen SA, Pharmaceuticals & Healthcare Deals By Type, 2012 to YTD 2018 9
Ipsen SA, Pharmaceuticals & Healthcare, Deals By Region, 2012 to YTD 2018 10
Ipsen SA, Deals By Therapy Area, 2012 to YTD 2018 11
Ipsen SA, Medical Devices Deals, 2012 to YTD 2018 13
Ipsen SA, Pharmaceuticals & Healthcare, Deals Summary, 2012 to YTD 2018 14
Ipsen Acquires Healthcare Portfolio from Sanofi for USD88.3 Million 18
Ipsen Acquires Oncology Assets from Merrimack Pharma 20
Rhythm Pharma Raises USD41 Million in Mezzanine Financing 22
Rhythm Metabolic Raises USD40 Million in Series A Financing Round 24
Rhythm Pharma Raises US$33 Million In Series B Financing 26
Motus Therapeutics Secures Additional USD8 Million in Series B Round of Venture Funding 28
Rhythm Pharma Raises US$9.5 Million In Venture Financing 30
Arix Bioscience and Ipsen Enter into Co-Development Agreement 31
Ipsen Enters into Co-Promotion Agreement with Saol Therapeutics 32
Ipsen Enters into Research Agreement with Institute of Molecular and Cell Biology 33
Ipsen Partners with Oncodesign 34
Ipsen Enters into Research Agreement with PeptiMimesis 35
Ipsen Enters into Research Agreement with Aepodia 36
Galderma Enters into Distribution Agreement with Ipsen for Dysport in Asia-Pacific 37
Ipsen Enters into Research Agreement with Interprotein 38
Ipsen and EpiVax Enter into Partnership 39
Ipsen Enters into Research Agreement with Hannover Medical School 40
Ipsen and CNRS Enter into Agreement with CEA and University of Rennes 41
Ipsen Extends Research Agreement with Salk Institute for Biological Studies 42
Ipsen Extends Distribution Agreement with Galderma for Dysport 43
GW Pharma Enters Into Distribution Agreement With Ipsen For Sativex 45
Ipsen And Mayoly Spindler Enter Into Cross-Promotion Agreement For Primary Care Activities In France 46
Ipsen Enters Into Research Agreement With Harvard Medical School To Discover Botulinum Toxins 47
PeptiDream Expands Co-Development Agreement With Ipsen For Peptide Drugs 48
PeptiDream Enters Into Research Agreement With Ipsen To Discover Therapeutic Peptides 49
Oncodesign And Laboratory For Neurobiology and Gene Therapy Enter Into Research Agreement With Ipsen For Parkinson's Disease 50
Ipsen Extends Distribution Agreement With Galderma For Dysport 52
Oncodesign Enters into Research Agreement with Ipsen 53
Ipsen Enters into Licensing Agreement with MD Anderson 54
Merrimack Pharma Enters into Licensing Agreement with Ipsen 55
Ipsen Amends Licensing Agreement with Exelixis 56
Ipsen Enters into Licensing Agreement with 3B Pharma 57
Ipsen Enters into Licensing Agreement with Telesta Therapeutics 58
Lexicon Pharma Expands Licensing Agreement with Ipsen 59
Otonomy Enters into Licensing Agreement with Ipsen 60
Lexicon Pharma Expands Licensing Agreement with Ipsen for Telotristat Etiprate 61
Ipsen Enters into Licensing Agreement with Probi 63
Daewoong Enters Into Licensing Agreement With Ipsen Tianjin For Smecta Technology 64
Ipsen Enters Into Licensing Agreement With Inspiration Biopharma For IB1001 and OBI-1 65
Arix Bioscience to Raise USD76.7 Million in Private Placement of Shares 66
Ipsen Raises USD341 Million in Public Offering of 1.875% Notes Due 2023 68
Baxter International Completes Acquisition Of Rights To OBI- 1 And Related Assets From Ipsen And Inspiration Biopharma For USD700 Million 69
Cangene Completes Acquisition Of Rights To Hemophilia Products From Ipsen And Inspiration For US$300 Million 71
Ipsen to Acquire Equity Stake in Akkadeas Pharma 73
Ipsen Acquires Canbex Therapeutics 74
Ipsen Acquires OctreoPharm Sciences for USD57 Million 75
Ipsen Acquires Syntaxin, Life Sciences Company, For USD206 Million 76
Ipsen Sells 19.31% Stake In Spirogen, Developer Of DNA Sequence-Targeted Agents 78
Ipsen SA, Key Competitors 79
Ipsen SA, Key Employees 80
Ipsen SA, Subsidiaries 82
Ipsen SA, Affiliate 84
Ipsen SA, Joint Venture 84
List of Figures
Ipsen SA, Pharmaceuticals & Healthcare, Deals by Type, 2012 to YTD 2018 2
Ipsen SA, Pharmaceuticals & Healthcare, Deals By Year, 2012 to YTD 2018 2
Ipsen SA, Pharmaceuticals & Healthcare, Deals By Region, 2012 to YTD 2018 2
Ipsen SA, Pharmaceuticals & Healthcare, Deals By Therapy Area, 2012 to YTD 2018 2
Ipsen SA, Pharmaceuticals & Healthcare, Deals By Year, 2012 to YTD 2018 8
Ipsen SA, Pharmaceuticals & Healthcare, Deals by Type, 2012 to YTD 2018 9
Ipsen SA, Pharmaceuticals & Healthcare, Deals By Region, 2012 to YTD 2018 10
Ipsen SA, Pharmaceuticals & Healthcare, Deals By Therapy Area, 2012 to YTD 2018 11
Ipsen SA, Medical Devices Deals, 2012 to YTD 2018 13